Indifferent ( = not interested; not caring)
Incorrect : He is indifferent at politics.
Correct : He is indifferent to politics.
Incorrect : I was totally indifferent with the cold.
Correct : I was totally indifferent to/ towards the cold.
Note: The noun ‘indifference’ also takes the same preposition.
For example:
He showed complete indifference to/towards me.
The antonym of ‘indifferent’ is not ‘different’.