Do with and Do to
Incorrect : What have you done to my pen? I can't find it.
Correct : What have you done with my pen? I can't find it.
Incorrect : What have you done with my pen? It doesn't write.
Correct: What have you done to my pen? It doesn't write.
Note: "What have you done with my pen?” means “Where is it?” But “What have you done to it?” suggests that you have damaged it.
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